Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval
نویسندگان
چکیده
منابع مشابه
The significance of premature luteinization in an oocyte-donation programme.
BACKGROUND Several evidences indicate that premature luteinization (PL) may affect IVF outcome. The primary end-point of the present study was to verify the effect of PL on the pregnancy rate (PR) of our oocyte-donation programme. METHODS PL was defined as serum progesterone > or = 1.2 ng/ml on the day of HCG. We analysed retrospectively 240 oocyte-donation cycles in which 120 women donated t...
متن کاملHormone-stimulated secretion of luteinization factor in porcine granulosa cells.
Luteinization stimulator (LS) is an intrafollicular compound which was shown to be released by granulosa cells under in vitro conditions with stimulatory effects on immature granulosa cell differentiation. This study was undertaken to determine the effects of various endocrine agents which are involved in the regulation of ovarian function on LS secretion by porcine granulosa cells isolated fro...
متن کاملHypoxia Promotes Progesterone Synthesis During Luteinization in Bovine Granulosa Cells
To determine whether hypoxia has an effect on luteinization, we examined the influence of hypoxia on a model of bovine luteinizing and non-luteinizing granulosa cell culture. The granulosa cells were obtained from small antral follicles (≤ 6 mm in diameter). To induce luteinization, the cells were treated for 24 h with insulin (2 µg/ml), forskolin (10 µM) or insulin in combination with forskoli...
متن کاملLuteinization factor-stimulated steroidogenesis in porcine granulosa cells.
Luteinization stimulator (LS), an intrafollicular compound of preovulatory (5-8 mm) follicles, increased both the basal and gonadotropins-stimulated production of progesterone by immature (1-3 mm) granulosa cells. The mechanism by which LS enhance steroidogenesis was investigated by studying the modulation of progesterone biosynthesis from exogenous cholesterol and pregnenolone in cultured porc...
متن کاملWith low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization
BACKGROUND Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be for administration of ovulation-triggers. METHODS Fifty-six women ≥43, and ...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2015
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-15-0246